Description

Principal Scientist, Upstream - RNA

At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. R&D is committed to discovering and delivering transformational vaccines and medicines to prevent and change the course of disease.

We believe the Greater Boston area is an important hub for the biotech and pharma industry, which is why we've invested in growing our footprint and expanding our R&D space in Cambridge, with a primary focus on additional state-of-the-art lab space. Here, we will bring together talent and expertise, building upon GSK's long history of vaccine development, to create globally leading viral capabilities and cutting-edge vaccines technologies, as we add to our robust portfolio targeting infectious diseases at every stage of life.

This is a lab-based position with an anticipated 4-5 days on-site presence in the laboratory.

The Nucleic Acid Vaccines Center of Excellence (NAV CoE), a global team within the GSK's Drugs Substance Vaccine's Technical Research and Development organization, has as a mission to develop the next generation mRNA Drug Substance vaccine platforms for rapid development of new vaccine candidates. It has branches in Cambridge and in Rixensart, Belgium.

We are looking for a highly motivated Upstream Process Development Expert Scientist to join the mRNA Drug Substance (DS) team and work on delivering new mRNA vaccine candidates from development to the clinical manufacturing stages, a role located in Cambridge, MA USA, and reporting to the NAV CoE head (Belgium based). The position will play a significant role in shaping current and next generation GSK's mRNA vaccine platforms to accelerate addressing unmet medical needs, a compelling field having a direct impact into patients and global health. This exciting opportunity allows you to lead key activities, collaborate with top talents in the vaccines industry, and advance your career while ensuring timely project delivery in collaboration with process development colleagues and GMP team.

Key Responsibilities:

• Autonomously design, execute, and analyze experiments to develop and optimize RNA in-vitro transcription processes to translate into the mRNA platform and continuously evolve it, ensuring phase-appropriate and scalable processes, as part of the overall platform development strategy.
• Lead transversally process development activities of the upstream team and/ or any other additional initiatives that may arise.
• Work within a global team, proactively collaborate transversally with BE and US-based DS teams, Analytical R&D, GMP teams, etc, in an agile and open way ensuring good communication and alignment.
• Drive innovative solutions and meet project milestones.
• Stay up to date on industry trends and emerging technologies in downstream processing, contributing to continuous improvement initiatives.

Basic Qualifications:

We are looking for professionals with these required skills to achieve our goals:

• MS or PhD with degree in Molecular Biology, Biotechnology, Bioengineering, Chemical Engineering or a related scientific field
• Experience with RNA biology and mechanisms of eukaryotic translation.
• 5+ years of industry experience in process development for large biomolecules, preferably mRNA and pDNA, with hands-on experience in mRNA synthesis workflows
• Experience in overall process development and analytical development activities required for CMC support.

Preferred Qualifications:

If you have the following characteristics, it would be a plus:

• Experience with Quality by Design.
• Experience with DOE studies & process improvements, and advancements including parameter optimization, scale-up, process window determination, etc.
• Knowledge of the large molecule regulatory environment, particularly FDA/ICH/ISPE guidelines on risk management, technology transfer and process validation
• Experience and understanding in nucleic acid analytical technologies.

#LI-GSK

#Vx-Cam

The annual base salary for new hires in this position ranges from $113,025 to $188,375 taking into account a number of factors including work location within the US market, the candidate's skills, experience, education level and the market rate for the role. In addition, this position offers an annual bonus and eligibility to participate in our share based long term incentive program which is dependent on the level of the role. Available benefits include health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and paid caregiver/parental and medical leave.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases - to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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